Mitogen-Activated Protein Kinase (MAPK) signalling pathways represent a fundamental means by which cells translate extracellular stimuli into a wide array of intracellular responses, including ...

Researchers are combining a range of techniques for analyzing key cell signaling pathways in drug discovery and therapeutic development, according to presentations at Cambridge Healthtech’s “Molecular ...

Kinases, the enzymes that catalyze phosphorylation events, have been implicated in hundreds of different diseases, including cancer, inflammatory diseases, and neurological disorders. Compounds that ...

Raf kinases are components of the MAP kinase pathway, a signal transduc-tion pathway that normally controls cell growth and division downstream of activated cell surface growth factor receptors. RAF1, ...

NOTE. P < .00357 represents statistical significance after the Bonferroni correction. Abbreviations: MAPK, mitogen-activated protein kinase; NA, unable to be calculated; NR, not reached; OS, overall ...