A newly described stage of a lymph node-like structure seen in liver tumors after presurgical immunotherapy may be vital to successfully treating patients with hepatocellular carcinoma, according to a ...

A newly described stage of a lymph node-like structure seen in liver tumors after presurgical immunotherapy may be vital to successfully treating patients with hepatocellular carcinoma, according to a ...

How do tertiary lymphoid structures influence immunotherapy outcomes in Merkel cell carcinoma? Spatial proteomics reveals key ...

TLSs are highly organized structures that typically appear as clusters of B-cells containing FDCs. These clusters are then surrounded by T-cells and HEVs as shown schematically in Figure 1. We ...

The Nature Index 2025 Research Leaders — previously known as Annual Tables — reveal the leading institutions and countries/territories in the natural and health sciences, according to their output in ...

A research team at Memorial Sloan Kettering Cancer Center (MSK) has made new insights into how the body forms immune cell clusters called tertiary lymphoid structures (TLSs) in response to foreign ...

Exceptional responses in RCC are associated with higher clonal neoantigen load and enriched B-cell receptor signaling pathways. Tertiary lymphoid structure signatures and increased metabolic activity ...

Retrospective validation of a novel multimodal AI prognostic tool integrating digital pathology and clinical data against real world data and Oncotype DX in a Swiss breast cancer cohort. This is an ...

Tissue samples from head and neck cancer patients that show tumor “neighborhoods.” The image on the left is more diffuse because it has dysfunctional, exhausted immune cells, while the image on the ...