Histone deacetylation and other modifications, particularly the methylation of lysine 9 within histone H3 (H3-K9) residues located in the histone tails, cause chromatin condensation and block ...
Modification of histone tails, by acetylation, methylation or phosphorylation, affects the local chromatin structure and the transcriptional regulation of adjacent genes. Pericentric heterochromatin ...
Chromatin is structurally complex, consisting of DNA, histone and nonhistone proteins. The remodeling of the chromatin histone and nonhistone proteins around which the DNA is wrapped is a fundamental ...
Illustration of H2B or H3 tail-less nucleosomes. Nucleosomes lacking H2B and H3 tails exhibit weakened interactions between histone tails and nucleosomal DNA, leading to less stable nucleosome ...
Strands of DNA wrapped around a histone. Credit: Molekuul/Science Source Histones are among the most abundant proteins in the body. They act as spools that help compact DNA so our enormous genomes ...
Computer simulations visualize in atomic detail how DNA opens while wrapped around proteins. Researchers from the Hubrecht Institute in Utrecht (The Netherlands) and the Max Planck Institute for ...
In a recent study published in the journal Science Advances, a group of researchers investigated the role of histone modifications in human aging by developing and evaluating histone-specific age ...
KANAZAWA, Japan, April 24, 2024 /PRNewswire/ -- Researchers at Nano Life Science Institute (WPI-NanoLSI), Kanazawa University report in Nano Letters how the use of high-speed atomic force microscopy ...
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