Various approaches have been developed to identify and quantitate copy-number variation. A new, high-resolution approach that already shows promise is digital PCR. As illustrated by many research ...
Changes in genomic copy number can also occur via whole-genome doubling (WGD) and chromothripsis. These evolutionary events may be rampant during tumor development and can transpire into the evolution ...
Comparative genomic hybridization (CGH) was developed to identify pathogenic DNA copy-number changes (e.g., duplications, deletions) on a genome-wide scale, and to map these changes to genomic ...
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