Unwanted biomolecules need to be removed from serum, blood, urine, semen, spinal fluid, and other ex-vivo samples so that quantitative analysis of tiny molecules can be performed using LC-MS systems.
Solid-phase extraction (SPE) is the gold standard for sample preparation in chromatographic analysis. It is used to capture, clean, and concentrate samples while removing interfering compounds, ...
Liquid chromatography using tandem mass spectrometry detection (LC/MS/MS) is the technique of choice for small molecule bioanalyses in clinical and preclinical studies. Sample-preparation steps are ...