Crofelemer has been granted Orphan Drug Designation by the U.S. Food and Drug Administration (FDA) and the European Medicines ...

Although the gut renews itself constantly, its stem cells accumulate age-related molecular changes that quietly alter how ...

Although constipation and diarrhea may seem like opposite problems, they both hinge on the same underlying issue: how much fluid moves into the gut. These common issues affect millions of people in ...

Healthy digestion depends on a delicate balance of fluid in the gut. At the heart of that balance are epithelial cells, which line the intestinal wall and control how salt and water move in and out of ...

Scientists have uncovered a gut-specific epigenetic aging mechanism that links inflammation and iron imbalance to cancer risk ...

Researchers have discovered a way to help aging intestines heal themselves using CAR T-cell therapy. By targeting senescent ...

The intestinal epithelium undergoes rapid renewal every 3–5 days, a process driven by intestinal stem cells (ISCs) located at ...

Leaky gut syndrome (LGS) is a proposed digestive condition where the intestinal lining allows bacteria and toxins into the bloodstream. Symptoms include diarrhea, bloating, and fatigue. There is no ...

Intestinal fibrosis is a common and potentially serious complication of IBD that results from the reaction of intestinal tissue to the damage inflicted by chronic inflammation. The traditional view ...