Tumor growth is associated with profound metabolic and neurochemical alterations, which can lead to the onset of anorexia−cachexia syndrome. Anorexia is defined as the loss of the desire to eat, while ...

Atrophy of skeletal muscle in cancer cachexia results in weakness (asthenia) and death. Muscle mass is controlled by the rate of protein synthesis and the rate of protein degradation, which in the ...

Anti-cachectic effects of a novel peptide nucleic acid: Preliminary results of a phase 1/11 clinical trial Authors: J. T. D'Olimpio, S. Z. Hirschman, Z. Shtemer, and M. Didiego Authors Info & ...

Many people with cancer experience dramatic loss of muscle and fat tissue. In many cases, even the heart muscle is affected, which further weakens the body. This wasting syndrome, known as cachexia, ...

A recent Nature Metabolism study reports that circulating lactate levels are positively associated with weight loss in cancer cachexia patients. Mouse model experiments also revealed that ...

Sensitivity of cytology and immunohistochemistry for diagnosis of pancreaticobiliary cancer. Background: Advanced pancreatic adenocarcinoma is characterized by progressive weight loss and nutritional ...

Cancer cachexia, or the wasting syndrome, is a catastrophic condition that causes dramatic and involuntary loss of muscle mass, fat and weight, alongside extreme fatigue, anorexia and anemia in ...

Los Angeles, CA – August 14, 2025 – The Terasaki Institute for Biomedical Innovation announces a significant advancement in addressing the fight against cancer-associated cachexia (CAC), a ...